2013 Fiscal Year Final Research Report
Exploration of the role of microRNAs in nutrition response
| Project/Area Number |
24658118
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATO Hisanori 東京大学, 総括プロジェクト機構, 特任教授 (40211164)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | マイクロRNA / アミノ酸 / タンパク質栄養 / 遺伝子発現 / ロイシン |
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| Research Abstract |
Micro-RNAs (miRNA) are small RNAs that do not encode proteins and regulate the expression of a variety of genes by interacting with their mRNAs. Aiming at finding miRNAs that respond to nutritional conditions, we performed DNA microarray analysis. An interesting finding was the up-regulation of miR-149* in response to the deficiency of leucine, an essential amino acid. In addition, we manipulated the amount of miR-203, a miRNA which respond to low protein diet, in cultured cells. As miR-203 target, we identified Naa50, a factor involved in cancer and cell growth.
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