2012 Fiscal Year Final Research Report

Functional analysis and application of glutathiolated plant products

Research Project

Project/Area Number	24658122
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Food science
Research Institution	Nagoya University
Principal Investigator	UCHIDA Koji 名古屋大学, 生命農学研究科, 教授 (40203533)
Project Period (FY)	2012
Keywords	イソチオシアネート / イベリン / 抗炎症性 / 自然炎症 / グルタチオン / グルタチオン化 / 抱合体
Research Abstract	We have investigated the Toll-like receptor (TLR) signaling inhibitory potential of food-derived small molecules. Based on an extensive screening of Brassica vegetable extracts for the TLR-inhibitory activity, we found cabbage as the richest source and identified 3-(methylsulfinyl)propyl isothiocyanate (iberin), an analogue of sulforaphane isolated from broccoli, as one of the major TLR inhibitor in cabbage. We also studied glutathiolation and protein reactivity of iberin.