2013 Fiscal Year Final Research Report
High-resolution analysis of bioresponse of functional food factor on the basis of metabolomics
| Project/Area Number |
24658124
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
FUJIMURA Yoshinori 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (20390304)
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| Co-Investigator(Kenkyū-buntansha) |
SETOYAMA Daiki 九州大学, 先端融合医療レドックスナビ研究拠点, 特任助教 (30550850)
MIURA Daisuke 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (40532627)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | メタボロミクス / MALDI-MS / マトリックス / 質量分析イメージング / 代謝物プロファイリング |
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| Research Abstract |
In this study, we attempted to develop a technique and methodology, understanding of MALDI ionization rationale and synthesis of new matrix, for improvement of molecular coverage and detection sensitivity toward high-resolution metabolite analysis on the basis of MALDI-MS capable of sensitively detecting metabolites from trace amount of cells. We succeeded in newly proposing a methodology of chemometric prediction of MALDI ionization based on the quantitative structure-property relationship (QSPR) analysis and in newly generating highly sensitive matrix for metabolites. In addition, we found new molecular mechanism, mitochondrial regulation system, of oxidative stress, which is often observed in biological responses against food factors.
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[Journal Article] MALDI efficiency of metabolites quantitatively associated with their structural properties : a quantitative structure-property relationship (QSPR) approach2014
Author(s)
Yukihira D, Miura D, Fujimura Y, Umemura Y, Yamaguchi S, Funatsu S, Yamazaki M, Ohta T, Inoue H, Shindo M, Wariishi H
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Journal Title
J Am Soc Mass Spectrom
Volume: 25
Pages: 1-5
DOI
Peer Reviewed
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[Presentation] MALDI-MSを用いた代謝物分析における代謝物化学構造とイオン収率との定量的構造特性相関2013
Author(s)
行平大地,三浦大典,藤村由紀,梅村佳克,山口真一,船津慎治,山﨑真,太田哲也,井上裕章,新藤充,割石博之
Organizer
第8回メタボロームシンポジウム
Place of Presentation
福岡市
Year and Date
20131003-04
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