2013 Fiscal Year Final Research Report
Development of IgA-Immune Complex Vaccine for the Prevention and Treatment of Allergy
| Project/Area Number |
24658128
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Kyoto Women's University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 食物アレルギー / 母乳哺育 / IgA免疫複合体 / 飲むワクチン / 経口免疫寛容 |
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| Research Abstract |
We found existence of food allergens as immune complexes with specific IgAs in mother's milk and have proposed a hypothesis that mother's milk is a natural drinkable vaccine for food allergy prevention. In this research, we proved that both natural IgA immune complex prepared from human saliva and pseudo immune complex which chemically coupled ovalbumin with IgA showed vaccine function as a direct factor for tolerance induction in mice. In addition, we clarified reinforcement effect by the probiotics on this tolerance induction.
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