Synthetic studies on the active substances for fruiting body induction using glycolipid model compounds having sugar-lipid hybrid structures

2014 Fiscal Year Final Research Report

• Project/Area Number: 24658160
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Wood science
• Research Institution: Forestry and Forest Products Research Institute
• Principal Investigator: NISHIMURA Takeshi 独立行政法人森林総合研究所, 木材改質研究領域, 主任研究員 (10353799)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 子実体誘導物質 / 化学合成 / 構造活性相関 / グルコシルセラミド / グリセロ糖脂質

Outline of Final Research Achievements

Sugar-lipid hybrid structures are expected to be effective for fruit body induction. Then, compounds library including glyceroglycolipid analogs and glucosylceramides with various designed structures were constructed based on chemical synthetic approach. From the fruiting assay against Pleurotus ostreatus by paper disc method, the structure-activity relationship depending on the numbers of glucose units, carbon numbers of acyl chains, and differences in aglycon structures were suggested. Finally, the chemical substances which stimulate hyphal aggregation and primordia formation at fairly low concentration (10μg/disk for a glyceroglycolipid analog, 1μg/disk for a glucosylceramid) were successfully found in the assessment of the minimum effective dose.

Free Research Field

木材化学