2013 Fiscal Year Final Research Report
Instability of proteins from aquatic animals as revealed by molecular dynamics simulation
| Project/Area Number |
24658186
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Fisheries chemistry
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | タンパク質 / 構造揺らぎ / 不安定性 / 魚介類 / 分子シミュレーション |
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| Research Abstract |
Molecular dynamics simulation was applied to the mechanism of instability of proteins (namely, tropomyosin, myoglobin and myosin) from some aquatic organisms. The extent of structural fluctuations under varied temperature and pressured conditions were examined in detail. Regarding the two proteins except myosin, the regions responsible for the instability could be identified. Especially in case of tropomyosin, the effects of amino acid substitutions on the bends in the molcule could be addressed. On the other hand, in the case of myoglobin, the detaied study revealed the extent of fluctuation under the wide range of temperature and pressured conditions, which might be a possible factor for the molecular adaptation of each animal species to the respective habitat.
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