2013 Fiscal Year Final Research Report
Study on physiological role for novel peptide, NU1 and NU2
| Project/Area Number |
24658247
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Tetsuro 宮崎大学, フロンティア科学実験センター, 准教授 (30264352)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAZATO Mikiya 独立行政法人国立循環器病研究センター, 生化学部, 部長 (50291183)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 新規ペプチド / 摂食 / 体温 |
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| Research Abstract |
Intracerebroventricular (icv) injection of novel peptide, NU1 and NU2, increased the food intake and body temperature in a dose-dependent manner in rats. When expression of mRNA levels in the hypothalamus and midbrain/brainstem after icv injection of these peptides were examined using gene tip analysis, prostaglandin E synthetase mRNA and cyclooxygenase mRNA expressions increased dramatically. On the other hand, pretreatment with indomethacin completely blocked the increase of body temperature induced by NU1 and NU2. These results suggest that NU1 and NU2 increase the body temperature through prostaglandin E.
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