A role for Annexin A5 in the pregnancy

2013 Fiscal Year Final Research Report

• Project/Area Number: 24658249
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Kitasato University
• Principal Investigator: KAWAMINAMI Mitsumori 北里大学, 獣医学部, 教授 (00153007)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: アネキシンA5 / 不育症 / 血小板 / 凝固 / 抗リン脂質症候群

Research Abstract

Annexin A5 (Anxa5) is a calcium dependent phospholipid binding protein and a member of annexin family proteins. While it has been assumed that Anxa5 would be involved in the anticoagulant action in the placenta, there has no direct evidence. We have demonstrated that Anxa5 has a crucial role in the anticoagulation during pregnancy by using Anxa5 knockout mice. We confirmed that aggregation of platelets occurred in the placenta of Anxa5KO. We have reported this already (Sci, Rep. 2. 827).

Research Products

• [Journal Article] Loss of maternal annexin A5 increases the likelihood of Placental platelet thrombosis and foetal loss (2012)
  • Author(s): Ueki H, Mizushina T, Laharatchatathanin T, Terashima R, Nishimura Y, Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Brachyogel B, Poschl E, Kawaminami M
  • Journal Title: Scientific reports Volume: 2 Pages: 827
  • DOI: 10.1038/srep00827
  • Peer Reviewed
• [Presentation] アネキシンA5ノックアウトマウスの黄体形成ホルモン(LH)分泌 (2013)
  • Author(s): 小野寺桃子,水品智菜,尾崎優,武藤顕一郎,米澤智洋,久留主志朗,汾陽光盛
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜市(岐阜県)
  • Year and Date: 2013-09-20
• [Presentation] ラット発情前期の黄体形成ホルモン(LH)サージに伴う下垂体前葉でのアネキシンA5の変化 (2013)
  • Author(s): 汾陽光盛,中村祐希,米澤智洋,久留主志朗
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜市(岐阜県)
  • Year and Date: 2013-09-20
• [Presentation] Annexin A5 of maternal blood is prerequisite for preventing fetal loss during intact pregnancy (2012)
  • Author(s): Kawaminami M, Ueki H, Nidhimuts Y, Rieanrakwong D, Yonezawa T, Kurusu S
  • Organizer: The Endocrine Society's 94th Annual Meeting
  • Place of Presentation: Houston, Texas, USA
  • Year and Date: 2012-06-24
• [Patent(Industrial Property Rights)] 細胞増殖抑制剤 (2012)
  • Inventor(s): 汾陽光盛
  • Industrial Property Rights Holder: 学校法人北里研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 5320719
  • Acquisition Date: 2012-07-06
  • Overseas