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2013 Fiscal Year Final Research Report

Pathological study of AA amyloidosis in vaccinated white hens and

Research Project

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Project/Area Number 24658254
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionGifu University

Principal Investigator

ISHIGURO Naotaka  岐阜大学, 応用生物科学部, 教授 (00109521)

Co-Investigator(Kenkyū-buntansha) YANAI Tokuma  岐阜大学, 応用生物科学部, 教授 (10242744)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsアミロイド / ニワトリ / ワクチン / 伝達
Research Abstract

Outbreaks of systemic amyloidosis in flocks of layers are known to be induced by repeated inflammatory stimulation with multiple vaccinations with oil-emulsified bacterins. Outbreaks of fatal AA amyloidosis were observed in vaccinated growing chickens in a large scale poultry farm. Amyloid deposits were observed in postmolten examination of dead hens, suggesting that vaccinations with Salmonella Enteritidis (SE) would be considered as a potential risk for the development of AA amyloidosis. To determine the transmission of chicken AA amyloidosis among white hens, we induced experimental AA amyloidosis in vaccinated chickens by intravenous or oral administration of chicken AA fibrils. Amyloid deposits were observed in chickens ingected with SE and inouculated with chicken AA fibrils intravenously and orally. These results suggest that chicken AA amyloidosis can be induced by vaccinations, and may be transmitted among species.

  • Research Products

    (7 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] AA amyloidosis in vaccinated growing chickens2013

    • Author(s)
      T. Murakami, Y. Inoshima, E. Sakamoto, H. Fukushi, H. Sakai, T. Yanai and N. Ishiguro
    • Journal Title

      J. comp. Path

      Volume: 149 Pages: 291-297

    • DOI

      10.1016/j.jcpa.2013.02.002

    • Peer Reviewed
  • [Journal Article] Experimental induction and oral transmission of avian AA amyloidosis in vaccinated white hens2013

    • Author(s)
      Tomoaki Murakami, Naeem Muhammad, Yasuo Inoshima, Tokuma Yanai, Masanobu Goryo and Naotaka Ishiguro
    • Journal Title

      Amyloid

      Volume: 20 Pages: 80-85

    • DOI

      10.3109/13506129.2013.783474

    • Peer Reviewed
  • [Presentation] 育成鶏に認められたAAアミロイド-シスの病理学的特徴2012

    • Author(s)
      村上智亮、猪島康雄、酒井洋樹、福士秀人、石黒直隆、柳井徳磨
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手大学
    • Year and Date
      20120914-16
  • [Presentation] ニワトリを用いた実験的AAアミロイドーシスの誘発2012

    • Author(s)
      村上智亮、猪島康雄、柳井徳磨、御領政信、石黒直隆
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手大学
    • Year and Date
      20120914-16
  • [Presentation] 実験的AAアミロイドーシスの伝播2012

    • Author(s)
      村上智亮、猪島康雄、石黒直隆
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手大学
    • Year and Date
      20120914-16
  • [Presentation] ニワトリの肝臓における微生物汚染とアミロイド沈着2012

    • Author(s)
      石黒直隆、村上智亮、猪島康雄
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手大学
    • Year and Date
      20120914-16
  • [Presentation] Potential induction of vaccine-associated amyloid A amyloidosis in white young hens2012

    • Author(s)
      Tomoaki Murakami, Yasuo Inoshima, Masakazu Inagaki, Eigo Sakamoto, Syouzou Sakamoto, Tokuma Yanai and Naotaka Ishiguro
    • Organizer
      XIII International Symposium on Amyloidosis
    • Place of Presentation
      Groningen, The Netherlands
    • Year and Date
      20120506-10

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Published: 2015-06-25  

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