2014 Fiscal Year Final Research Report
Basic study for development of a novel method for bovine mastitis
| Project/Area Number |
24658260
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied veterinary science
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| Research Institution | Rakuno Gakuen University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 乳房炎 / 乳腺上皮細胞 / ＰＢＭＣ / 高度治療技術 |
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| Outline of Final Research Achievements |
Mycoplasma bovis is known as a significant pathogen and cause of large economic losses in beef and dairy calves worldwide. Numerous factors appear to play an important role in the development of disease during infection with M. bovis, e.g., inhibition of immune cell proliferation and induction of lymphocyte apoptosis. However, the mechanisms involved in M. bovis infections have not been explored and remain incompletely understood. We investigated the major cytokine mRNA expression of bovine mammary epithelial cells and bovine PBMC stimulated with M. bovis, and established mixed culture system for the evaluation of phage function. We clarified significant changes of cytokine gene expression of PBMC stimulated with M. bovis, and established mixed culture system consisted with mammary epithelial cells and PBMC. These results are important to develop novel methods to treat mycoplasma mastitis in dairy cows.
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| Free Research Field |
獣医衛生学
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