• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Genomic analysis of histiocytic proliferative disorders in Pembroke Welsh corgi dog

Research Project

  • PDF
Project/Area Number 24658263
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Clinical veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

UCHIDA Kazuyuki  東京大学, 農学生命科学研究科, 准教授 (10223554)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords組織球性肉腫 / イヌ / 遺伝子異常 / コーギー
Research Abstract

The aim of this research project is to clarify the molecular pathogenesis of the histiocytic sarcomas in Pembroke Welsh corgi dogs (PWC). To know the prevalence of histiocytic sarcomas of the PWC in Japan, an epidemiological study for histiocytic sarcomas of dogs in Veterinary Medical Center of the University of Tokyo, was conducted. The results revealed the high incidence of histiocytic sarcomas in the PWC, unlike the previous reports from foreign countries. We also analyzed the DNA of the affected PWC using next-generation sequencers, but so far yet to identify the gene mutations directly associated to tumoregenesis of histiocytic sarcomas. Besides, the cell line from histiocytic sarcoma from a PWC dog has been successfully established, that would be the useful experimental tools for the investigation of the tumoregenesis of histiocytic sarcoma in PWC dogs.

  • Research Products

    (3 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Clinical Characteristics and Prognostic Factors in Dogs with Histiocytic Sarcomas in Japan2014

    • Author(s)
      Takahashi M, Tomiyasu H, Hotta E, Asada H, Fukushima K, Kanemoto H, Fujino Y, Ohno K, Uchida K, Nakayama H, Tsujimoto H
    • Journal Title

      J Vet Med Sci

      Volume: (In press)

    • DOI

      10.1292/jvms.13-0414

    • Peer Reviewed
  • [Presentation] イヌ組織球性肉腫細胞におけるEMR4の機能解析およびシグナル探索2013

    • Author(s)
      坪井誠也,井手鉄哉,渡邊学,内田和幸,菅野純夫,中山裕之
    • Organizer
      2013獣医内科学アカデミー
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20130222-24
  • [Remarks]

    • URL

      http://www.vm.a.u-tokyo.ac.jp/byouri/research03/research03.htm

URL: 

Published: 2015-06-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi