2013 Fiscal Year Final Research Report
Development of Rotaxane-type Supramolecular Complexes Whose Ring Moves Upon Phosphorylation and Dephosphorylatoin
| Project/Area Number |
24659011
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
AOKI Shin 東京理科大学, 薬学部, 教授 (00222472)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | リン酸化 / 脱リン酸化 / ロタキサン / 超分子 / 酵素反応 / 分子機械 |
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| Research Abstract |
Molecular motors such as ATP synthetase are so-called "molecular motors" that utilize chemical bonding energy of ATP. The purpose of this project is to design and synthesize artificial supramolecular complexes, the structure of which are altered by enzymatic phosphorylation and dephosphorylation reactions. We have designed the rotaxane-like supramoleculer complexes that contain a macrocycle part (cyclodextrin (CyD)) and an axis part that is threaded through a CyD ring. In this work, we have succeed in the synthesis of the rotaxane molecule that contains an azobenzene unit as "Station " at the center of the axis and two Zn2+-cyclen complex units as "Station 2" at the edge of the axis.
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[Journal Article] Supramolecular Phosphatases Formed by the Self-Assembly of Bis(Zn^<2+>-cyclen) Complex, Copper(II), and Barbital Derivatives in Water (Cyclen = 1,4,7,10-Tetraazacyclododecane)2014
Author(s)
Mohd Zulkefeli, Yosuke Hisamatsu, Asami Suzuki, Yuya Miyazawa, Motoo Shiro, and Shin Aoki
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Journal Title
Chemistry-Asian Journal
Volume: (in press)
Peer Reviewed
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[Journal Article] Evaluation of Zinc (II) Chelators for Inhibiting p53-Mediated Apoptosis2013
Author(s)
Akinori Morita, Shinya Ariyasu, Soichiro Ohya, Ippei Takahashi, Bing Wang, Kaoru Tanaka, Takatoshi Uchida, Haruna Okazaki, Kengo Hanaya, Atsushi Enomoto, Mitsuru Nenoi, Masahiko Ikekita, Shin Aoki, and Yoshio Hosoi
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Journal Title
Oncotarget
Volume: 4 (12)
Pages: 2439-2450
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[Presentation] The Selective Capture and Collection of Live Target Cells using a Photoreactive Silicon Wafer Device Modified with Antibodies via Photocleavable Linkers2012
Author(s)
Ariyasu, S.; Hanaya, K.; Watanabe, E.; Hoshi, M.; Suzuki, T.; Horie, K.; Hayase, M.; Abe, R.; Aoki, S.
Organizer
13th Tetrahedron Symposium- Asia Edition-
Place of Presentation
Taipei, Taiwan(Elsevier Best Poster Award)
Year and Date
20121127-30
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[Presentation] Development of a Photoreactive Silicon Device Modified with Antibodies via Photocleavable Linkers for the Selective Capture and Collection of Live Target Cells2012
Author(s)
Aoki, S., Ariyasu, S.; Watanabe, E.; Hoshi, M.; Suzuki, T.; Horie, K.; Hayase, M.; Abe, R.
Organizer
17th Malaysian Chemical Congress (17MCC)
Place of Presentation
Kuala Lumpur, Malaysia
Year and Date
20121015-17
Invited
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[Presentation] Development of Photochemical Devices for Diagnosis and Treatment of Cancer2012
Author(s)
Aoki, S.; Ariyasu, S.; Hisamatsu, Y.; Moromizato, S.; Shibuya, A.; Watanabe, E.; Suzuki, T.; Hayase, M.; and Abe, R.
Organizer
1st International Postgraduate Conference on Pharmaceutical Sciences 2012 (iPoPS2012)
Place of Presentation
Puncak Alam, Malaysia (Plenary Lecture)
Year and Date
20120628-30
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