2013 Fiscal Year Final Research Report
Innovation of a novel technology for supporting the development of DDS drugs and protein medicines by controling their pharmacokinetics.
Project/Area Number |
24659021
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Physical pharmacy
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Research Institution | University of Shizuoka |
Principal Investigator |
OKU NAOTO 静岡県立大学, 薬学部, 教授 (10167322)
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Co-Investigator(Kenkyū-buntansha) |
ASAI Tomohiro 静岡県立大学, 薬学部, 准教授 (00381731)
SHIMIZU Kosuke 静岡県立大学, 薬学部, 助教 (30423841)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 薬学 / 長期血中滞留性 / 薬物送達システム / リポソーム / ファージディスプレイペプチドライブラリー / バイオパニング / ドラッグデリバリー / DDS |
Research Abstract |
In the development of drug nanocarriers in drug delivery systems or recombinant protein medicines, rapid blood clearance of these is frequently problematic. To overcome this rapid clearance, we attemped to obtain petides having long circulating characteristic by use of phage-displayed peptide library that presenting 5 mer random peptides. After intravenous injection of the library, we selected long circulating phages and identified long circulating peptides. Unfortunately, the circulating characteristics of drug nanocarriers was not improved by modifying the surface of them with the peptides. However, since cloned phages presenting these peptids showed quite long circulation in the bloodsteam of mice, we believe that these peptides are useful for the development of DDS drugs or protein drugs.
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Research Products
(7 results)
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[Presentation] Increased Half-life of secondly injected PEGylated liposomes in mice pretreated with doxorubicin-encapsulated PEGylated liposome2013
Author(s)
Jantana Yahuafai, Tomohiro Asai, Genki Nakamura, Yuri Kiyokawa, Yoshihito Takeuchi, Kosuke Shimizu, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
Organizer
International Liposome Society 2013 Meeting Liposome Advances : Progress in Drug and Vaccine Delivery
Place of Presentation
London, UK
Year and Date
2013-12-14
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[Presentation] Enhanced circulation of secondly injected PEGylated liposomes after injection of doxorubicin-encapsulatd PEGylated liposomes2013
Author(s)
Jantana Yahuafai, Yuri Kiyokawa, Yoshito Takeuchi, Daiki Saito, Kosuke Shimizu, Tomohiro Asai, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
Organizer
The 5 th Conference
Place of Presentation
名古屋
Year and Date
2013-08-05
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