2012 Fiscal Year Final Research Report
Alterations of proteolytic processing of synaptic adhesion molecules in Alzheimer disease
| Project/Area Number |
24659028
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TOMITA Taisuke 東京大学, 大学院・薬学系研究科, 准教授 (30292957)
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| Project Period (FY) |
2012
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| Keywords | 神経細胞 / シナプス / 接着分子 |
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| Research Abstract |
In brain, each single neuron is connected to other neurons via synapses. Synapses can change their strength in response to neuronal activity, and synaptic adhesion molecules are implicated in the synapse plasticity. However, the metabolism of the synaptic adhesion molecules remains unknown. In the research, we found that neuroligin 1, which is associated with autism spectrum disorder, is sequentially processed by two proteases. This processing is modulated by synaptic activity and negatively regulates synapse formation in vivo.
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[Journal Article] Effect of helical conformation and side-chain structure on 〓-secretase inhibition by 〓-peptide foldamers: Insight into substrate recognition.2013
Author(s)
Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, To mita T, Higuchi T
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Journal Title
J Med Chem
Volume: 56(4)
Pages: 1443-1454
DOI
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[Journal Article] Activity-dependent Cleavage of Neuroligin 12012
Author(s)
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N,Koyama R, Tomita T, Iwatsubo T
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Journal Title
Neuron
Volume: 76(2)
Pages: 410-422
DOI
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