2013 Fiscal Year Final Research Report
Elucidation of the molecular mechanisms of immunological tolerance in liver
| Project/Area Number |
24659032
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 免疫学 / 免疫寛容 / 肝臓 |
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| Research Abstract |
Liver exhibits the feature of immunological tolerance. Although several mechanisms have been suggested, it still remain unclear. In this study, we found that an immunosuppressive cytokine expression was higher in liver than in spleen of naïve mice. Moreover, we found that liver sinusoidal endothelial cells, which exist only in liver, enhanced an immunosuppressive cytokine expression by the stimulation of other cytokine. These findings would lead to the understanding of immunological tolerance and the therapy for several liver diseases.
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