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2013 Fiscal Year Final Research Report

Regulation of mammalian neuronal system by a novel microRNA "mirtron".

Research Project

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Project/Area Number 24659033
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

MIZUGUCHI Hiroyuki  大阪大学, 薬学研究科(研究院), 教授 (50311387)

Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsmicroRNA / mirtron / セロトニン神経 / ストレス
Research Abstract

In this study, we revealed using knockout mice that mir-877, a mammalian-specific mirtron, regulated the functions of serotonergic neurons through suppression of gene X which is involved in serotonergic and adrenergic neural development, and also regulated the serum glucocorticoid level, which is a mediator of stress responces, through suppression of gene Y. Our findings suggested that mammalian-specific mirtrons could regulate varieties of central nervous functions.

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Published: 2015-06-25  

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