2013 Fiscal Year Final Research Report
Regulation of mammalian neuronal system by a novel microRNA "mirtron".
| Project/Area Number |
24659033
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | microRNA / mirtron / セロトニン神経 / ストレス |
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| Research Abstract |
In this study, we revealed using knockout mice that mir-877, a mammalian-specific mirtron, regulated the functions of serotonergic neurons through suppression of gene X which is involved in serotonergic and adrenergic neural development, and also regulated the serum glucocorticoid level, which is a mediator of stress responces, through suppression of gene Y. Our findings suggested that mammalian-specific mirtrons could regulate varieties of central nervous functions.
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