2013 Fiscal Year Final Research Report
Golgi stress response by proteoglycans
| Project/Area Number |
24659039
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NADANAKA Satomi 神戸薬科大学, 薬学部, 講師 (60378578)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | プロテオグリカン / 糖転移酵素 / 硫酸化糖鎖 / ノックアウトマウス / ガン抑制遺伝子 / ストレス応答 / リン酸化 / 脱リン酸化 |
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| Research Abstract |
Glycosaminoglycans (GAGs) are components of proteoglycans (PGs), which are abundant on the surfaces of most cells and in extracellular matrices. PGs are known to function as cofactors in a variety of biological processes. Most biological activities of PGs are attributed to the GAG side chains that interact with diverse protein ligands via specific saccharide sequences. EXTL2, a member of the EXT family of tumor suppressors, functions to suppress any GAG biosynthesis that is enhanced by a xylose kinase, and thus lack of EXTL2 causes GAG overproduction and structural changes to GAGs. These poor-quality GAGs have effects on the cell signaling such as HGF-mediated and BMP-mediated signaling, and consequently disturb liver regeneration and blood vessel remodeling. Therefore, the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a "quality control system" for PGs and GAGs produced in the absence of EXTL2 can be closely associated with diseases.
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Research Products
(10 results)
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[Journal Article] Glycosaminoglycan overproduction in the aorta increases aortic calcification in murine chronic kidney disease2013
Author(s)
Purunomo, E., Emoto, N., Nugrahaningsih, D., Nakayama, K., Yagi, K., Heiden, S., Nadanaka, S., Kitagawa, H., Hirata, K.
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Journal Title
J. Am. Heart Assoc.
Volume: 2(5)
Pages: e000405
DOI
Peer Reviewed
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[Journal Article] EXTL2, a member of EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner2013
Author(s)
Nadanaka, S., Zhou, S., Kagiyama, S., Shoji, N., Sugahara, K., Sugihara, K., Asano, M., Kitagawa, H.
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Journal Title
J. Biol. Chem.
Volume: 288(13)
Pages: 9321-9333
DOI
Peer Reviewed
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[Presentation] Altered cell surface heparan sulfate expressions induce osteoblastic differentiation and attenuate phagocytosis activity of human coronary artery smooth muscle cells (HCASMCs)2012
Author(s)
Purnomo, E., Emoto, N., Nugrahaningsih, D. A. A., Yagi, K., Nakayama, K., Nadanaka, S., Kitagawa, H., Hirata, K.
Organizer
第35回日本高血圧学会総会
Place of Presentation
名古屋
Year and Date
20120920-22
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[Book] Exostosin (multiple)-like 1-3 (EXTL1-3). Handbook of Glycosyltransferases and Related Genes, 2nd Ed2014
Author(s)
Nadanaka, S., Kitagawa, H.(Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., and Angata, T., eds)
Publisher
Springer (in press)
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