2013 Fiscal Year Final Research Report
Design and synthesis of anti-brain tumor and brain-protective drugs using brain-targeting peptides
| Project/Area Number |
24659048
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
OTSUKA Masami 熊本大学, 生命科学研究部, 教授 (40126008)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 脳腫瘍薬 / 脳保護薬 |
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| Research Abstract |
The present study aimed at the development of novel antitumor and cytoprotective molecules and the subsequent connection of brain-targeting devices. The activity of antitumor compound comprising dimethylaminopyridine and histidines was optimized by introducing appropriate substituents. A brain-targeting device was introduced to this molecule. On the other hand, an inositol phospholipid derivative having a dodecyl group in place of the diacyl glycerol group was synthesized as a brain-protective compound.
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[Journal Article] Design and synthesis of lipid-coupled inositol 1,2,3,4,5,6-hexakisphosphate derivatives exhibiting high-affinity binding for HIV-1 MA domain2014
Author(s)
Hiroshi Tateishi, Kensaku Anraku, Ryoko Koga, Yoshinari Okamoto, Mikako Fujita, Masami Otsuka
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Journal Title
Organic & Biomolecular Chemistry
Volume: First published online
DOI
Peer Reviewed
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[Journal Article] Poly-proline motif in HIV-2 Vpx is critical for its efficient translation2014
Author(s)
Ariko Miyake, Mikako Fujita, Haruna Fujino, Ryoko Koga, Sogo Kawamura, Masami Otsuka, Hirotaka Ode, Yasumasa Iwatani, Yosuke Sakai, Naoya Doi, Masako Nomaguchi, Akio Adachi, Yasuyuki Miyazaki
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Journal Title
Journal of General Virology
Volume: 95
Pages: 179-189
DOI
Peer Reviewed
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[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma2013
Author(s)
Tadashi Ashizawa, Haruo Miyata, Akira Iizuka, Masaru Komiyama, Chie Oshita, Akiko Kume, Masahiro Nogami, Mika Yagoto, Ichiro Ito, Takuma Oishi, Reiko Watanabe, Koichi Mitsuya, Kenji Matsuno, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yoko Nakasu, Ken Yamaguchi Yasuto Akiyama
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Journal Title
International Journal of Oncology
Pages: 219-227
DOI
Peer Reviewed
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[Journal Article] Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity2012
Author(s)
Shintaro Suemasu, Naoki Yamakawa, Tomoaki Ishihara, Teita Asano, Kayoko Tahara, Ken-ichiro Tanaka, Hirofumi Matsui, Yoshinari Okamoto, Masami Otsuka, Koji Takeuchi, Hidekatsu Suzuki, Tohru Mizushima
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Journal Title
Biochemical Pharmacology
Volume: 84 (11)
Pages: 1470-1481
DOI
Peer Reviewed
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