2014 Fiscal Year Final Research Report
Synthesis of PEGylated drug candidates for PET imaging
Project/Area Number |
24659049
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Drug development chemistry
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Research Institution | Osaka University (2013-2014) University of Shizuoka (2012) |
Principal Investigator |
AKAI Shuji 大阪大学, 薬学研究科(研究院), 教授 (60192457)
|
Co-Investigator(Renkei-kenkyūsha) |
OKU Naoto 静岡県立大学, 薬学部, 教授 (10167322)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | ポリエチレングリコール / クリック化学 / ペプチド / PEG化医薬品 / イメージング / 創薬 / フッ素アニオン / 蛍光色素 |
Outline of Final Research Achievements |
The covalent attachment of poly(ethylene glycol) (PEG) with an average molecular weight (Mw) of 5-40 kDa to a drug or a therapeutic protein, called PEGylation, is a common strategy to evade the host immune system, to enhance its stability in blood, etc. In this study, we have developed a synthetic method of PEGylated peptides, possessing a fluorescent moiety at one end of the PEG chain, which enabled noninvasive whole-body trafficking of such molecules in living rats.
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Free Research Field |
医薬化学
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