2014 Fiscal Year Final Research Report
Molecular targets and biological systems involved in the toxicity of nucleophilic organometallic compounds
| Project/Area Number |
24659058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ハイブリッド分子 / 有機金属化合物 / 細胞毒性 |
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| Outline of Final Research Achievements |
The organic-inorganic hybrid molecules have been widely used in the field of organoelement chemistry. However, very little is known about the toxicity of the molecules. To investigate the vascular toxicity of nucleophilic organometallic compounds, vascular endothelial cell were cultured and treated with diphenylditelluride, diphenyldiselenide, a model compound, in the present study. Cytotoxicity and intracellular accumulation were determined and the effects of an electron-donating group (CH3O-) and an electron-withdrawing group (-Cl) on the cytotoxicity of DPDTe were evaluated. The data obtained suggest that the endothelial cytotoxicity of nucleophilic organometallic compounds depends on the intramolecular metal and electronic structure in the compounds.
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| Free Research Field |
環境・衛生薬学，毒性学，バイオオルガノメタリクス
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