Development of non-invasive therapeutic drug monitoring method for pediatric patients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659066
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Gunma University
• Principal Investigator: YAMAMOTO Koujirou 群馬大学, 医学(系)研究科(研究院), 教授 (70174787)
• Co-Investigator(Kenkyū-buntansha): HASHITA Tadahiro 群馬大学, 大学院医学系研究科, 助教 (20613384) ; AOMORI Tohru 慶応義塾大学, 薬学部, 講師 (40620802)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬物濃度モニタリング / 高感度微量定量法

Outline of Final Research Achievements

The highly sensitive measurement method with very small amount of sample is essential for a noninvasive therapeutic drug monitoring. In addition, blood sample is not separated to plasma and blood cell in spot sampling, which is usually utilized for small amount blood sampling. Therefore, the evaluation of the distribution of drug to blood cell is necessary to understand the relationship of measured concentration with noninvasive sampling and conventional blood sampling. In this study, we established the highly sensitive quantitation method for darunavir, an anti HIV drug to determine the drug concentration in blood and blood cell. Large inter-individual variability was observed in blood cell / plasma concentration ratio of darunavir, which suggests the contribution of some drug transporter function.

Free Research Field

臨床薬理学