2013 Fiscal Year Final Research Report
Search for key molecules for intestinal virus entry
| Project/Area Number |
24659068
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
TAKADA Tappei 東京大学, 医学部附属病院, 講師 (90376468)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 薬理学 / 生理学 / 脂質 / トランスレーショナルリサーチ / トランスポーター |
|---|
| Research Abstract |
Recently, NPC1L1, which mediates the intestinal cholesterol absorption and is a molecular target of ezetimibe for dyslipidemia, is actively studied and several important physiological functions other than cholesterol transport have been revealed. The aim of this study was to prove the hypothesis that intestinal transporters such as NPC1L1 are important for virus entry. Since in vitro and in vivo models for the experiments of intestinal virus entry are arranged, key molecules for virus entry from the small intestine should be revealed in the near future.
|
