Analysis of the control mechanism of Neuronal migration by new stratagem.

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659082
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: University of Fukui
• Principal Investigator: KURODA Kazuki 福井大学, 医学部, 助教 (60557966)
• Co-Investigator(Kenkyū-buntansha): SATO Makoto 大阪大学, 連合小児発達学研究科, 教授 (10222019) ; XIE Min-jue 福井大学, 医学部, 助教 (40444210) ; IGUCHI Tokuichi 大阪大学, 医学(系)研究科(研究所), 助教 (60509305)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 神経細胞 / 細胞移動 / 興奮性神経細胞 / 抑制性神経細胞 / 転写因子

Research Abstract

Cell migration is an essential process in the embryogenesis and maintenance of multicellular organisms. The cerebral cortex contains the excitatory and inhibitory neurons, these neurons arise in the differential region of cerebral cortex. The excitatory neurons move from the ventricular zone to the cortical plate by the radial migration and the inhibitory neurons move from the ganglionic eminence to the cerebral cortex by the tangential migration. The forced expression of the transcriptional factor Ptf1a induced the tangential migration on the developing excitatory neurons. The Ptf1a targeting genes were searched by the microarray analysis. Some targeted genes were upregulated in the Ptf1a-expressing excitatory neurons, but these Ptf1a targeted genes were not involved in tangential migration on functional analysis. We are modifying the screening method for the tangential migration-related genes.

Research Products

• [Journal Article] Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective neuronal migration and neuronal circuit formation in lissencephaly (2013)
  • Author(s): Toba, S., Tamura, Y., Kumamoto, K., Yamada, M., Takao, K., Hattori, S., Miyakawa, T., Kataoka, Y., Azuma, M., Hayasaka, K., Amamoto, M., Tominaga, K., Wynshaw-Boris, A., Wanibuchi, H., Oka, Y., Sato, M., Kato, M. and Hirotsune, S.
  • Journal Title: Sci. Rep. Volume: 3 Pages: 1224
  • Peer Reviewed
• [Journal Article] Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of embryonic myoblasts (2013)
  • Author(s): Kuroda, K., Kuang, S., Taketo, MM. and Rudnicki, MA.
  • Journal Title: Skelet Muscle Volume: 3(1) Pages: 5
  • Peer Reviewed
• [Journal Article] Smoothened controls cyclinD2 expression and regulates the generation ofintermediate progenitors in the developing cortex (2013)
  • Author(s): Komada, M., Iguchi,T., Takeda, T., Ishibashi, M. and Sato, M.
  • Journal Title: Neurosci. Lett. Volume: 547 Pages: 87-91
  • Peer Reviewed
• [Journal Article] Episodic memory retrieval for story characters in high-functioning autism (2013)
  • Author(s): Komeda, H., Kosaka, H., Saito, N-D., Inohara, K., Munesue, T., Ishitobi, M., Sato, M. and Okazawa, H.
  • Journal Title: Molecular Autism Volume: 4(1) Pages: 20
  • Peer Reviewed
• [Journal Article] Long-term oxytocin administration improves social behaviors in a girl with autistic disorder (2012)
  • Author(s): Kosaka, H., Munesue, T., Ishitobi, M., Asano, M., Omori, M., Sato, M., Tomoda, and Wada, Y.
  • Journal Title: BMC Psychiatry Volume: 12(1) (case report) Pages: 110
  • Peer Reviewed
• [Journal Article] Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization (2012)
  • Author(s): Takitoh, T., Kumamoto, K., Wang C.-C., Sato, M., Toba, S., Wynshaw-Boris, A. and Hirotsune, S.
  • Journal Title: J. Neurosci. Volume: 32(32) Pages: 11050-11066
  • Peer Reviewed
• [Journal Article] Effects of antidepressants and mood stabilizers on serum levels of adiponectin (2012)
  • Author(s): Omata, N., Murata, T., Narita, K., Maruoka, N., Mitsuya, H., Mita, K., Nishimoto, T., Sato, M. and Wada, Y.
  • Journal Title: NeuroEndocrinol. Lett. Volume: 33(1) Pages: 1-2
  • Peer Reviewed
• [Journal Article] WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration (2012)
  • Author(s): Xie, M.-J., Yagi, H., Kuroda, K., Wang C.-C., Komada, M., Zhao, H., Sakakibara, A., Miyata, T., Nagata, K., Oka, Y., Iguchi, T. and Sato, M.
  • Journal Title: Cerebral Cortex Volume: 23(6) Pages: 1410-1423
  • Peer Reviewed
• [Presentation] 神経細胞のスパインにおけるFILIP関連分子の生体における機能解析 (2014)
  • Author(s): 黒田一樹、謝敏カク、尾身実、八木秀司、佐藤真
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 栃木県下野市 (ポスター)
  • Year and Date: 2014-03-28
• [Presentation] FILIP-related molecule controls spine maturation and synaptic function in the hippocampal neuron via non-muscle myosinIIb (2013)
  • Author(s): Kuroda, K., Yagi, H., Xie, M.-J., Oka, Y., Iguchi, T. and Sato, M.
  • Organizer: Society For Neuroscience 2013
  • Place of Presentation: 米国サンディエゴ (ポスター)
  • Year and Date: 2013-11-11
• [Presentation] 神経細胞の棘突起(スパイン)におけるLUZPの機能解析 (2013)
  • Author(s): 黒田一樹
  • Organizer: 第14回ORIGIN神経科学研究会夏のワークショップ
  • Place of Presentation: 岐阜県下呂市 (一般口演)
  • Year and Date: 2013-08-31
• [Presentation] FILIP関連分子によるMyosin-IIbを介した神経細胞野スハ?イン形成の制御とシナプス可塑性における機能解析(FILIP-related molecule controls spine maturation and synaptic function in the hippocampal neuron via non-muscle myosinIIb) (2013)
  • Author(s): 黒田一樹,八木秀司,謝敏カク,岡雄一郎,猪口徳一,佐藤真
  • Organizer: Neuro2013
  • Place of Presentation: 京都府京都市 (ポスター)
  • Year and Date: 2013-06-21
• [Presentation] 神経細胞の棘突起(スパイン)形成におけるFILIP関連分子の機能解析 (2013)
  • Author(s): 黒田一樹,謝敏カク,猪口徳一,岡雄一郎,尾身実,王振吉,八木秀司,佐藤真
  • Organizer: 第118回日本解剖学会全国学術集会
  • Place of Presentation: 香川県高松市 (ポスター)
  • Year and Date: 2013-03-30
• [Presentation] FILIP-related molecule controls spine maturation in the hippcampal neuron via non-muscle myosin llb (2012)
  • Author(s): Kuroda, K., Yagi, H., Xie, M.-J., Oka, Y., Iguchi, T., and Sato, M.
  • Organizer: The 11^<th> Biennial Meeting of the Asian-Pacific Society for Neurochemistry / 55^<th> Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: 兵庫県神戸市 (ポスター)
  • Year and Date: 2012-09-29
• [Presentation] 神経細胞の棘状突起(スパイン)形成におけるLUZPの機能解析 (2012)
  • Author(s): 黒田一樹
  • Organizer: ORIGIN神経科学研究会夏のワークショップ
  • Place of Presentation: 石川県小松市 (一般口演)
  • Year and Date: 2012-09-01
• [Book] 脳科学辞典(Web版)の「終脳」の項目
  • Author(s): 黒田一樹、佐藤真
  • URL: http://bsd.neuroinf.jp/wiki/