2013 Fiscal Year Final Research Report

Effects of SIRT1 activation on Teratogenesis

Research Project

Project/Area Number	24659086
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	General anatomy (including Histology/Embryology)
Research Institution	Nara Institute of Science and Technology
Principal Investigator	NAKAHATA Yasukazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50390810)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	先天異常学・奇形学
Research Abstract	Somite formation giving rise to the backbone occurs with an accurate periodicity during embryogenesis in vertebrates. It has been known that Hes7 is the one of the core clock genes for somitogenesis. We investigated whether SIRT1, a NAD+ dependent deacetylase, is concerned in somitogenesis by generating presomitic mesoderm-specific SIRT1 knockout mice. Our study has suggested that SIRT1 regulates Hes7 gene expression and Hes7 protein stability.

(2 results)