2013 Fiscal Year Final Research Report
Effects of SIRT1 activation on Teratogenesis
| Project/Area Number |
24659086
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
NAKAHATA Yasukazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50390810)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 先天異常学・奇形学 |
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| Research Abstract |
Somite formation giving rise to the backbone occurs with an accurate periodicity during embryogenesis in vertebrates. It has been known that Hes7 is the one of the core clock genes for somitogenesis. We investigated whether SIRT1, a NAD+ dependent deacetylase, is concerned in somitogenesis by generating presomitic mesoderm-specific SIRT1 knockout mice. Our study has suggested that SIRT1 regulates Hes7 gene expression and Hes7 protein stability.
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