2013 Fiscal Year Final Research Report
Development of imaging changes in microenvironment with in the sentinel lymph node combined with micrometastasis of carcinoma cells
| Project/Area Number |
24659098
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Yoshiko 信州大学, 医学部, 准教授 (10362112)
NAGAI Takashi 信州大学, 医学部, 助教 (50514353)
AJIMA Kumiko 信州大学, 医学部, 助教 (70584051)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 病態生理 / センチネルリンパ節 / 微小環境 / 癌転移 |
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| Research Abstract |
Metastasis of carcinoma cells mainly occurs through the lymphatic system, and the extent of metastasis in lymph nodes is clinically used as a useful prognostic indication. The clinical importance of SLN has been proven in many breast cancer patients. However, the biological and histological properties of lymphatic endothelial cells (LEC) in the SLN that interact with micrometastatic carcinoma cells remain unclear. Therefore, using the human breast carcinoma cell line MDA-MB-231, we have attempted to examine the effects of supernatants cultured with the cell line on the expression of adhesion molecules on human LEC and then to investigate whether the expressed adhesion molecules accelerate the attachment of carcinoma cells to the LEC. The experimental findings suggest that MDA-MB-231 may release or leak ATP, which produces the overexpression of ICAM-1 on human LEC through activation of purinergic receptors and then facilities ICAM-1-mediated attachment of carcinoma cells to the LEC.
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[Journal Article] Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis2013
Author(s)
Hosaka K, Yang Y, Seki T, Nakamura M, Andersson P, Rouhi P, Yang X, Jensen L, Lim S, Feng N, Xue Y, Li X, Larsson O, Ohhashi T, Cao Y
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Journal Title
Nat. Comm.
Volume: 4(article number)
Pages: 2129
Peer Reviewed
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