2013 Fiscal Year Final Research Report
Iprovement of metabolic and exercise function of skeletal muscles through activation of transcription factor, and prevention of obesity-related liver disease
| Project/Area Number |
24659104
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Kaoru 筑波大学, 医学医療系, 准教授 (00192162)
YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852)
YAMAMOTO Masakazu 東京女子医科大学, 医学部 (60220498)
KAWAKAMI Koji 京都大学, 医学系研究科 (70422318)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肥満性肝疾患 / 骨格筋 / 転写因子 / 代謝機能 / 運動機能 |
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| Research Abstract |
In the maximum exercise tolerance test, the running distance was significantly shorter in Nrf2KO mice than in wild-type mice. The distance became longer in the wild-type mice with Nrf2 activation by an Nrf2 activator. The ameliorating effect of exercise on liver steatosis of high sucrose and fat fed mice was observed in the wild-type mice but not in the Nrf2KO mice. Therefore, we developed cultured myocytes from mouse muscle tissues and studied the effect of exercise on myokine production in the cells. Upon electrical stimulation, the production of IL-6, a myokine, was markedly increased in the cells. It is likely that expression levels in myocytes is an important factor influential on exercised-induced myokine production in the muscles.
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[Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress2014
Author(s)
Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T
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Journal Title
J Dermatol Sci
Volume: 74
Pages: 9-17
Peer Reviewed
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[Journal Article] Expression of N-acetylglucosaminyl- transferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder2014
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J
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Journal Title
J Gastroenterol
Volume: 49
Pages: 702-714
Peer Reviewed
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[Journal Article] Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2013
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Gotoh N, Tokushige K, Hashimoto E, Utsunomiya H, Takahashi H, Ishii T, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 48
Pages: 620-32
Peer Reviewed
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[Journal Article] Glycoproteomics-based cancer marker discovery adopting dual enrichment with Wisteria floribunda agglutinin for high specific glyco-diagnosis of cholangio- carcinoma2013
Author(s)
Matsuda A, Kuno A, Matsuzaki H, Kawamoto T, Shinkai T, Nakanuma Y, Yamamoto M, Ohkohchi N, Ikehara Y, Shoda J, Hirabayashi J, Narimatsu H
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Journal Title
J Proteomics
Volume: 85
Pages: 1-11
Peer Reviewed
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[Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain2013
Author(s)
Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, Sakurai T
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Journal Title
J Neuroscience
Volume: 33
Pages: 14767-14777
Peer Reviewed
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[Journal Article] Negative expression of N-acetylglucosamyl- transfererase V in oral squamous cell carcinoma correlates with poor prognosis2013
Author(s)
Seto K, Uchida F, Baba O, Yamatoji M, Karube R, Warabi E, Yanagawa T, Onizawa K, Miyoshi E, Shoda J, Bukawa H
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 47
Pages: 924-35
Peer Reviewed
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[Presentation] 肝内胆管癌の新規糖蛋白質マーカーの開発2013
Author(s)
小貫建一郎,樋口亮太,谷澤武久,梶山英樹,川本徹,山本雅一,中沼安二,大河内信弘,松田厚志,久野敦,成松久,正田純一
Organizer
第49回胆道学会
Place of Presentation
千葉
Year and Date
20130919-20
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