2013 Fiscal Year Final Research Report
Analysis of mechanisms underlying strain recognition memory in mice using visualization techniques
| Project/Area Number |
24659108
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kochi University |
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Principal Investigator |
KABA Hideto 高知大学, 教育研究部医療学系, 教授 (50136371)
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| Co-Investigator(Kenkyū-buntansha) |
OKUTANI Fumino 高知大学, 教育研究部医療学系, 准教授 (10194490)
TANIGUCHI Mutsuo 高知大学, 教育研究部医療学系, 助教 (10304677)
MURATA Yoshihiro 高知大学, 教育研究部医療学系, 助教 (40377031)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 匂い / 記憶 / 副嗅球 / 可視化 / 発火パターン / 代謝型グルタミン酸受容体 / Ca2+チャネル / バゾプレッシン |
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| Research Abstract |
By using transgenic mice that stably express the green fluorescent protein (GFP) coupled to the activity-dependent gene c-fos in mitral and granule cells naturally activated by the association of mating male chemosignals and mating signal in the accessory olfactory bulb (AOB), we found in AOB slices that GFP-positive mitral cells fired in burst mode in contrast to GFP-negative mitral cells that fired in tonic mode. In addition, we found in AOB slices prepared from normal mice that the activation of mGluR2 on mitral cells in the AOB inhibited voltage-dependent Ca2+ channels, thereby suppressing the release of glutamate from the mitral cells and that vasopressin that enhances the induction of long-term potentiation at the mitral-to-granule cell synapse in the AOB reduced dendrodendritic inhibition of mitral cells.
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