2013 Fiscal Year Final Research Report
Epigenetic regulation involved in osteoclast differentiation
| Project/Area Number |
24659115
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIKAWA Keizo 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (30516290)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 破骨細胞 / エピジェネティクス / 転写因子 / 転写制御 / 細胞内代謝 / メタボライト / SAM / DNAメチル化 |
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| Research Abstract |
Although transcriptional regulation involved in osteoclast differentiation has extensively studied, epigenetics in osteoclasts have poorly understood. Our studies have demonstrated that methyltransferase enzyme whose expression is increased during osteoclastogenesis play an important role in osteoclast differentiation.
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[Journal Article] Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo2013
Author(s)
Kagawa Y, Matsumoto S, Kamioka Y, Mimori K, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M
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Journal Title
PLoS one
Volume: 30
Pages: e8362
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