2013 Fiscal Year Final Research Report
Identification of phosphatidylglycerophosphate-binding proteins.
| Project/Area Number |
24659124
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Akita University |
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Principal Investigator |
TAKASUGA SHUNSUKE 秋田大学, 医学(系)研究科(研究院), 助教 (90375262)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細胞内シグナル伝達 / リン脂質 |
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| Research Abstract |
Phosphatidylglycerophosphate (PGP) is a mitochondrial glycerophospholipid, known as a precursor of cardiolipin. We tried to identify PGP-binding proteins in mitochondria for elucidation of unique physiological functions of PGP. However, none of mitochondrial proteins containing known phospholipid binding domains binds PGP. Therefore, PGP-binding proteins might have a novel lipid-binding domain.
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Research Products
(6 results)
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[Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine2013
Author(s)
Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Chida S, Kontani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T
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Journal Title
Proc Natl Acad Sci USA
Volume: 110
Pages: 1726-31
DOI
Peer Reviewed
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