2012 Fiscal Year Final Research Report
Effects of Change in Purine Metabolism on Accumulation of Aggregated Proteins in the Cell
| Project/Area Number |
24659144
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NISHINO Takeshi 東京大学, 大学院・農学生命科学研究科, 特任教授 (40094312)
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| Co-Investigator(Kenkyū-buntansha) |
KUSANO Teruo 日本医科大学, 医学部, 助教 (30434129)
MIYAGAWA Takuya 東京大学, 大学院・農学生命科学研究科, 助教 (50596559)
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| Project Period (FY) |
2012
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| Keywords | 筋萎縮性側索硬化症 / キサンチン酸化還元酵素 / 抗痛風剤 / 活性酸素 |
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| Research Abstract |
We orally administered recently introduced potent xanthine oxidoreductase inhibitors, whose mechanisms of inhibition are well characterized, to ALS G1H-G93A mice. The results of modelexperiments indicated that orally administered non-purine analogue XOR inhibitors significantly delaythe disease progression. The protective effect is suggested to be due to increased removal ofaggregated protein accompany with change in purine metabolism by the experiment with modelsystems.
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