2013 Fiscal Year Final Research Report
Analysis of islet amyloid in Japanese type 2 diabetic patients and exploration of new treatment for diabetes
| Project/Area Number |
24659158
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Hirosaki University |
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Principal Investigator |
YAGIHASHI Soroku 弘前大学, 医学(系)研究科(研究院), 教授 (40111231)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 糖尿病 / β細胞 / アミロイド / マクロファージ / 炎症 / 膵ランゲルハンス島 / 病理 / 形態計測 |
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| Research Abstract |
We investigated islet amyloid deposition in Japanese type 2 diabetic patients. Different from high prevalence in Western diabetic patients, amyloid deposition was found in 28% of Japanese patients, occupying 18% area of the islet. The amyloid-rich diabetic group was associated with high BMI, indicating the implication of insulin resistance in the evolution of amyloid deposition. The beta cell volume density in amyloid-rich diabetic group was significantly smaller than that in amyloid-free diabetic group, suggesting that amyloid promotes the beta cell decline. The amyloid deposition was also accompanied by robust infiltration of activated macrophages. Thus, the intervention of the amyloid deposition and consequent inflammatory sequelae could be a novel target for the treatment of type 2 diabetes.
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Research Products
(24 results)
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[Journal Article] Exendin-4 improves β -cell function in autophagy-deficient β-cells2013
Author(s)
Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H
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Journal Title
Endocrinology
Volume: 154
Pages: 4512-4524
DOI
Peer Reviewed
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