Development of diagnostic agent for dementia

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659169
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: ISHIGAMI Akihito 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50270658)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 認知症 / 臨床検査試薬 / アルツハイマー病 / 老化 / シトルリン化タンパク質

Outline of Final Research Achievements

Peptidylarginine deiminases (PADs) are post-translational modification enzymes that citrullinate protein arginine residues. Abnormal protein citrullination by PAD2 has been closely associated with the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). In this study, we tried to develop a novel method for sandwich enzyme-linked immunosorbent assay (ELISA) for the determination of citrullinated proteins which may become a useful marker of human neurodegenerative diseases.

Free Research Field

神経変性疾患