Pathogen eradication mediated by receptor for IgM natural antibody

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659175
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: University of Tsukuba
• Principal Investigator: HONDA Shinichiro 筑波大学, 医学医療系, 准教授 (60360640)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: Fc受容体 / 自然抗体 / 敗血症

Research Abstract

Natural IgM antibody recognizes various pathogen components and contributes to eradication of pathogens. We found that mice lacking IgM Fc receptor, Fca/mR (CD351), showed reduced inflammatory cytokines production against lipopolysaccharide (LPS) and improved survival against septic shock. We also found that marginal zone B cells (MZBs), highly expressing Fca/mR, largely contribute inflammatory cytokines production against LPS. Thus, Fca/mR regulates inflammatory cytokine production from MZB, leading to the regulation of systemic inflammatory responses during LPS-induced septic shock.

Research Products

• [Journal Article] Involvement of Fcα/μR (CD351) in autoantibody production (2013)
  • Author(s): Yoshizawa Y, Honda S, Shibuya A.
  • Journal Title: Mol Immunol Volume: 57(2) Pages: 216-219
  • DOI: 10.1016/j.molimm.2013.10.002
  • Peer Reviewed
• [Journal Article] Molecular characterization of the dimer formation of Fcα/μreceptor (CD351) (2013)
  • Author(s): Takagaki K, Satoh K, Honda S, Shibuya A.
  • Journal Title: Mol Immunol Volume: 56(1-2) Pages: 23-27
  • DOI: 10.1016/j.molimm.2013.04.003
  • Peer Reviewed
• [Journal Article] Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells (2013)
  • Author(s): Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura K, Ohara O, Shibuya A, Wakeland E K, Li Q-Z, Miyazaki T.
  • Journal Title: Cell Reports Volume: 3 Pages: 1-12
  • DOI: 10.1016/j.celrep.2013.03.006
  • Peer Reviewed
• [Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor (2012)
  • Author(s): Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A.
  • Journal Title: J Exp Med Volume: 209(8) Pages: 1493-1503
  • DOI: 10.1084/jem.20120096
  • Peer Reviewed
• [Presentation] Involvement of CD300a in the pathogenesis of DSS-induced colitis (2013)
  • Author(s): Totsuka N, Kim YG, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会
  • Place of Presentation: 学術集会幕張メッセ(千葉)
  • Year and Date: 2013-12-13
• [Presentation] Fcα/μR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock (2013)
  • Author(s): Honda S, Yoshizawa Y, Sato K, Fujimoto M, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会
  • Place of Presentation: 学術集会幕張メッセ(千葉)
  • Year and Date: 2013-12-12
• [Presentation] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells (2013)
  • Author(s): Arai S, Honda S, Shibuya A, Li Q-Z, Miyazaki T.
  • Organizer: 第42回日本免疫学会総会
  • Place of Presentation: 学術集会幕張メッセ(千葉)
  • Year and Date: 2013-12-11
• [Presentation] Fcα/μR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock (2013)
  • Author(s): Honda S, Satoh K, Matsuoka Y, Matsushita T, Fujimoto M, Shibuya A.
  • Organizer: 15^<th> International Congress of Immunology
  • Place of Presentation: Mico Milano Congressi, Milan, Italy
  • Year and Date: 2013-08-23
• [Presentation] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor (2012)
  • Author(s): Nakahashi-Oda C, Tahara-Hanaoka S, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A.
  • Organizer: 第41回日本免疫学会国際シンポジウム(41^<th> International Symposium of Japanese Society of immunology, Kobe.)
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2012-12-06
• [Presentation] Follicular dendritc cells (FDC) internalized IgM-coated antigen via Fc receptor for IgA/IgM (Fcα/μR; CD351) (2012)
  • Author(s): Sato K, Usui K, Honda S, Yoshizawa Y, Shibuya A.
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2012-12-05
• [Remarks] つくばリポジトリ
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/simple-search?query=%E6%9C%AC%E5%A4%9A+%E4%BC%B8%E4%B8%80%E9%83%8E
• [Remarks] TRIOS
  • URL: http://trios.tsukuba.ac.jp/researcher/0000001684