2013 Fiscal Year Final Research Report
Analysis of mechanism of human herpesvirus-6-induced immune suppression
| Project/Area Number |
24659206
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Kobe University |
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Principal Investigator |
MORI YASUKO 神戸大学, 医学(系)研究科(研究院), 教授 (50343257)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 分子 / 細胞 / ヘルペスウイルス |
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| Research Abstract |
Primary infection and reactivation of HHV-6 have been reported to induce immunosuppression in host. The mechanism behind this phenomenon is unknown. We have identified the downregulation of CD6 on HHV-6-infected cells. Here we found that CD6 was dramatically downregulated at the late phase of infected cells, and we also searched for the viral genes responsible for this downregulation and found several genes which might be associated with this phenomenon. Our findings may contribute to elucidating the mechanism of immunosuppression induced by HHV-6 infection.
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Research Products
(3 results)
