New DC-mediated machinery to fine-tune excessive immune responses

2012 Fiscal Year Final Research Report

• Project/Area Number: 24659219
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
• Project Period (FY): 2012
• Keywords: 血球貪食 / 免疫寛容 / DC / IL-10 / 過剰免疫応答

Research Abstract

Henophagocytpsis is conventionally viewed as an indicator of severe inflammation. We established a murine model for hemophagocytosis. Using this model, we newly found that DC-mediated hemophagocytosis is the machinery to fine-tune excessive immune responses and assure host survival under severe infectious and inflammatory conditions.

Research Products

• [Journal Article] 樹状細胞による新しい免疫寛容誘導の仕組み (2013)
  • Author(s): 小内伸幸,大八木秀明,澤田賢一,樗木俊聡
  • Journal Title: 医薬ジャーナル Volume: 49 Pages: 95-100
• [Presentation] Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses during chronic virus infection (2012)
  • Author(s): Onai N, Ohyagi H, Sato T, Yotsumoto S, Kurabayashi K, Sawada K, and Ohteki T
  • Organizer: 2012 Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2012-12-07
• [Presentation] Role for monocyte-derived dendritic cells in fine-tuning excessive immune responses (2012)
  • Author(s): Ohteki T
  • Organizer: The 12th InternationalSymposium on Dendritic Cells
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2012-10-09
• [Presentation] Monocyte-derived dendritic cells perform hemophagocytosis to controlexcessive immune response (2012)
  • Author(s): Onai N, Ohyagi H, Sato T, Yotsumoto S,Kurabayashi K, Hosoi-Amaike M, Sawada K, and Ohteki T
  • Organizer: The 12thInternational Symposium on Dendritic Cells
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2012-10-09
• [Presentation] Monocyte-derived dendritic cells perform hemophagocytosis to fine-tuneexcessive immune responses (2012)
  • Author(s): Ohteki T
  • Organizer: The 11th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji
  • Year and Date: 2012-09-14
• [Presentation] Dendritic cells hemophagocytose to fine-tune immune responses (2012)
  • Author(s): 樗木俊聡
  • Organizer: 第22回日本樹状細胞研究会
  • Place of Presentation: 福島
  • Year and Date: 2012-06-15
• [Book] 標準免疫学第3版 (2013)
  • Author(s): 樗木俊聡
  • Total Pages: 219-225
  • Publisher: 医学書
• [Remarks] 東京医科歯科大学難治疾患研究所生体防御学分野HP
  • URL: http://www.tmd.ac.jp/mri/bre/index.html