2013 Fiscal Year Final Research Report
A novel strategy for treatment of psychiatric disorder based on a new regulation mechanism of prefrontal dopamine release
| Project/Area Number |
24659261
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUDA Toshio 大阪大学, 薬学研究科(研究院), 教授 (00107103)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ドパミン / σ1受容体 / 5-HT1A受容体 |
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| Research Abstract |
In the present study, we examined the mechanisms underlying the synergistic effect of combined serotonin reuptake inhibition and sigma-1 receptor activation on prefrontal dopaminergic transmission in circulating steroid hormone-deficient conditions. We also tried to clarify the signal molecules which involved the interaction between the serotonin system and sigma system. We found that combined activation of serotonin-1A and sigma-1 receptors has a synergistic effect on prefrontal dopaminergic transmission under circulating steroid deficiency, VTA-PFC system plays a key role in the combinded effect, and GABA(A) receptor is involved in the effect of the stroid hormone-deficient conditions. Unfortunately, we could not find the in vitro system including functional setrotonin-1A and sigma-1 receptors in the same cell.
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