In vivo validation of a novel anti-inflammatory peptide pharmaceutical

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659263
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: KAZUKI Okamoto 聖マリアンナ医科大学, 医学部, 准教授 (40177085)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 抗炎症剤 / ステロイド薬 / NF-κB / コリプレッサー / バイオ医薬品 / ペプチド医薬品

Outline of Final Research Achievements

I have found a small nuclear acidic protein (abbreviated as MTI-II), which works as a co-repressor for NF-κB and directly inhibits the transcriptional activity of NF-κB. The MTI-II will become a good anti-inflammatory agent without severe side effects, instead of the steroidal anti-inflammatory drug (SAID). I constructed the fusion protein of MTI-II and the protein transduction domain (MAID) and showed that the MAID had the strong anti-inflammatory activity in vivo. The aim of this study is to verify practical effectiveness of the MAID on the SAID adaptation disease (the mite-antigens induced atopic dermatitis mice and the collagen-induced arthritis rats).

Free Research Field

生化学・分子生物学