2012 Fiscal Year Final Research Report
Blood DNA test for breast cancer susceptibility
| Project/Area Number |
24659278
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SUEHIRO Yutaka 山口大学, 大学院・医学系研究科, 准教授 (40290978)
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| Project Period (FY) |
2012
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| Keywords | 膵がん / コピー数多型 |
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| Research Abstract |
Copy number polymorphisms (CNP) is one of genetic variations and involve gains or losses of several to hundreds of kilobases of genomic DNA among phenotypically normal individuals. Recent studies have described associations of CNPs with various common disorders as well as mental illness. Although CNPs are expected to affect pancreatic cancer, little is known about this association. These gap, in our knowledge, prompted us to study this relation. Array comparative genomic hybridization was performed to search for candidate CNPs related to pancreatic cancer susceptibility. We found 10 CNP markers associates with pancreatic cancer risk. The frequency of the CNPs were 55-70% in patients with pancreatic cancer and 0-7% in controls. These findings may lead a new means of risk assessment for pancreatic cancer.
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