2014 Fiscal Year Final Research Report
Mitochondrial DNA analysis for Alzheimer disease cohort study
| Project/Area Number |
24659281
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
KANG DONGCHON 九州大学, 医学(系)研究科(研究院), 教授 (80214716)
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| Co-Investigator(Renkei-kenkyūsha) |
KIYOHARA Yutaka 九州大学, 大学院医学研究科, 教授 (80161602)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ミトコンドリアDNA / アルツハイマー病 / コホート研究 |
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| Outline of Final Research Achievements |
The mitochondrial DNA sequences in the two regions (D-loop and ND6) have been determined for about 1.5 thousand residents in Hisayama town, Fukuoka prefecture. We have found thatone single nucleotide polymorphism (SNP) is statistically linked to Alzheimer disease. We are planning to establish the cybrid cell lines which contain the SNP and to analyze their mitochondrial activities, energy metabolism, and so on.
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| Free Research Field |
臨床検査医学
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