2014 Fiscal Year Final Research Report
Challenges to analyse "placebo-induced analgesia"
| Project/Area Number |
24659291
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKE Sachiko 九州大学, 医学(系)研究科(研究院), 准助教 (80253425)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | placebo / analgesia / animal model / running wheel / anxiety / emotion / prefrontal cortex / amygdala |
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| Outline of Final Research Achievements |
(1) As an animal model of "placebo-induced analgesia", the effects of non-opioid analgesic drugs were conditioned in rats and mice with inflammatory pain. We have established the new assessment system to evaluate the changes of spontaneous activity and emotions such as anxiety, in addition to pain thresholds.
(2) We have shown that the reduction of anxiety is conditioned simultaneously with analgesia, and that the prefrontal cortex and amygdala are involved in "placebo-induced analgesia." The study is still in progress.
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| Free Research Field |
Neuroscience
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