2013 Fiscal Year Final Research Report
The applications of ultrasonic vocalization of rodents to the developmental and neurotoxicological test-battery of sociality
| Project/Area Number |
24659296
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Hokkaido University |
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Principal Investigator |
WADA HIROMI 北海道大学, 文学研究科, 教授 (90191832)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 超音波発声 / ラット / 甲状腺ホルモン |
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| Research Abstract |
The high-dose and low-dose groups exhibited increased number and duration of ultrasonic vocalizations under maternal separation on PND 15 compared with the control group. However, perinatal hypothyroidism did not affect the frequencies of ultrasonic vocalizations under maternal separation. Hypothyroidism causes developmental retardation. Hypothyroid pups might need maternal care for much longer period and consequently, they still emitted ultrasonic vocalizations on PND 15. Perinatal hypothyroidism did not affect ultrasonic vocalizations under paring in adulthood. Therefore, the effects of perinatal hypothyroidism on ultrasonic vocalization disappear until adulthood.
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