2013 Fiscal Year Final Research Report
Exploration of immunological risk factors for osteoporosis
| Project/Area Number |
24659298
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 免疫 / 骨粗鬆症 / 疫学研究 / 骨密度 / 抗体 |
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| Research Abstract |
The aim of the study was to explore potential risk factors for osteoporosis and its related health conditions in epidemiologic studies. Immunological and inflammation markers in serum were measured, and their associations with bone mass and cognitive function were tested. Serum Cytomegalovirus antibody titers were significantly correlated with spinal bone mineral density in the Yokogoshi Study (r=-0.12), and Cytomegalovirus antibody titers were significantly correlated with 2-year changes in Mini-Mental State Examination scores in the Yamato Study (r=0.30). It is concluded that previous viral infection could predict osteoporosis and/or cognitive decline.
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