2014 Fiscal Year Final Research Report
Development of a new method of age estimation-an approach from transcription factors-
| Project/Area Number |
24659335
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
IIDA Reiko 福井大学, 医学部, 准教授 (40139788)
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| Co-Investigator(Renkei-kenkyūsha) |
UEKI Misuzu 福井大学, 医学部, 助手 (00165656)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 法医学 / 年齢推定 / 転写因子 |
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| Outline of Final Research Achievements |
I have identified a number of genes which were up- or down-regulated by siRNA-mediated knockdown of M-LPH or Rhit. No significant differences in histological appearance were observed between Rhit-/Rhit- mice and wild-mice. It was shown that RhitH binds to the Ttk 69K binding site and functions as a transcriptional repressor in M-LPH expression, and that expression of RhitH gene is transcriptionally regulated by two transcription factors, FOXD3 and GABP.
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| Free Research Field |
法医学、分子生物学
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