2013 Fiscal Year Final Research Report
Calorie restriction associated microRNA: Possibility of biomarkers of human aging-dependent diseases
| Project/Area Number |
24659351
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nagasaki University |
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Principal Investigator |
SHIMOKAWA Isao 長崎大学, 医歯(薬)学総合研究科, 教授 (70187475)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takahiro 長崎大学, 大学院医歯薬学総合研究科, 教授 (40284674)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Ryoichi 長崎大学, 大学院医歯薬学総合研究科, 講師 (30509310)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 老年医学 / microRNA / バイオマーカー |
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| Research Abstract |
MicroRNAs (miRNAs) belong to a small, non-coding RNA family and regulate the translational process of target messenger RNAs (mRNAs). It is reported that miRNAs circulate throughout a body (as circulating miRNA, c-miRNA), and that some c-miRNA expressions are altered with the physiological condition. We investigated the function of c-miRNAs in human blood plasma and their application as a biomarker. We identified the c-miRNAs associated with hypertension and obesity by using quantitative PCR, which suggested that c-miRNAs might regulate the metabolic state among distant organs. Thus, the identification of c-miRNAs in blood plasma has a high potential use both for diagnosis and for establishing a therapeutic target among lifestyle-related diseases.
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