2014 Fiscal Year Final Research Report
Analysis of a novel transcriptional repressor involved in energy metabolism and application for metabolic liver diseases
| Project/Area Number |
24659360
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOTA Yoshifumi 福井大学, 医学部, 教授 (50222386)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 糖代謝 / インスリンシグナル |
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| Outline of Final Research Achievements |
A dominant-negative transcriptional repressor, Id2 has been shown to regulate cell differentiation and proliferation. Id2 knockout mice have lean phenotype. Id2 deficiency conferred resistance to obesity and fatty liver development in a mouse model. Id2 knockout mice showed increased glucose tolerance and insulin sensitivity. Id2 was induced by insulin and mediated by phosphatidylinositol-3 kinase pathway. An increase of Id2 expression by insulin may be indispensable for adipocyte differentiation. Modulation of Id2 expression is thought to be a potential therapeutic target for fatty liver, metabolic syndrome, and furthermore, lifestyle-related diseases.
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| Free Research Field |
消化器内科
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