Molecular mechanisms of acinar cell injury in acute pancreatitis

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659364
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: TAKEHARA Tetsuo 大阪大学, 医学(系)研究科(研究院), 教授 (70335355)
• Co-Investigator(Kenkyū-buntansha): TATSUMI Tomohide 大阪大学, 大学院医学系研究科, 助教 (20397699) ; HIKITA Hayato 大阪大学, 大学院医学系研究科, 寄附講座 助教 (20623044) ; SHIGEKAWA Minoru 大阪大学, 大学院医学系研究科, 医員 (00625436)
• Co-Investigator(Renkei-kenkyūsha): IKEZAWA Kenji 大阪大学, 大学院医学系研究科, 大学院生
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 急性膵炎 / アポトーシス / マウスモデル

Research Abstract

STAT3 is a transcription factor which controls several gene expression levels associated with cell proliferation, inflammation, and cell survival. In the study, we clarified STAT3 played a protective role in pancreatic necrosis, inflammatory cell infiltration and apoptotic cell death using caerulein-administrated conditional STAT3 knockout mice, In the models of caerulein or L-arginine-induced acute pancreatitis, while the expression levels of Bcl-xL and Mcl-1 (anti-apoptotic proteins) increased, the severity of pancreatitis did not worsen in conditional Bcl-xL knockout mice compared with control mice. Collectively, these results suggested that Bcl-xL and Mcl-1may function redundantly in regulation of acute pancreatitis.

Research Products

• [Journal Article] 急性膵炎における転写因子の関わり (2014)
  • Author(s): 重川稔、竹原徹郎
  • Journal Title: 膵臓 Volume: 29 Pages: 38-44
  • Peer Reviewed
• [Journal Article] Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction (2012)
  • Author(s): Shigekawa M, Hikita H, Kodama T, Shimizu S, Li W, Uemura A, Miyagi T, Hosui A, Kanto T, Hiramatsu N, Tatsumi T, Takeda K, Akira S, Takehara T.
  • Journal Title: Am J Pathol Volume: 101 Pages: 2105-2113
  • Peer Reviewed
• [Presentation] セルレイン急性膵炎において膵STAT3はPAP1の分泌を介して膵保護的に働く (2013)
  • Author(s): 重川稔、岩橋潔、池澤賢治、竹原徹郎
  • Organizer: 第44回日本膵臓学会大会
  • Place of Presentation: 仙台
  • Year and Date: 20130725-26
• [Presentation] Pancreatic STAT3 protects caerulein-induced acute pancreatitis in mice via the PAP1 induction (2012)
  • Author(s): Minoru Shigekawa, Hayato Hikita, Takahiro Kodama, Satoshi Shimizu, Takuya Miyagi, Atsushi Hosui, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi and Tetsuo Takehara.
  • Organizer: DDW2012
  • Place of Presentation: San Diego, USA
  • Year and Date: 20120519-22
• [Remarks] データ更新中
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/research_a.html