2013 Fiscal Year Final Research Report
Activated hepatic stellate cell specific antibody that attenuates liver fibrosis: mechanism of action and therapeutic use
| Project/Area Number |
24659367
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANNO Keishi 広島大学, 病院, 助教 (30448237)
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| Co-Investigator(Renkei-kenkyūsha) |
SENTANI Kazuhiro 広島大学, 医歯薬保健学研究院, 助教 (30508164)
NISHIMICHI Norihisa 広島大学, 保健管理センター, 研究員 (00583486)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | インテグリン / 線維症 / 星細胞 / TGF-β / 抗体医薬 / 肝硬変 |
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| Research Abstract |
We have previously generated an anti-integrin alpha8beta1 blocking antibody, which has been found to inhibit liver fibrosis in mouse models. In the present study, we aimed at the mechanism of the profibrotic activity of integrin alpha8beta1. We found that 1) alpha8beta1 activates TGF-beta that plays major roles in fibrosis, and 2) alpha8beta1 supports emergence of myofibroblast that is a constituent of fibrotic tissues. The activation was previously fond also in other integrins, but the myofibroblast induction was a novel finding.
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