2012 Fiscal Year Final Research Report
Development of technology capable of promoting tissue remodeling without stimulating tissue fibrosis and cancer growth
| Project/Area Number |
24659378
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KOJIMA Soichi 独立行政法人理化学研究所, 分子リガンド生物研究チーム, チームリーダ (10202061)
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| Project Period (FY) |
2012
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| Keywords | Transglutaminase 2 (TG2) / Tumor (cancer) / Retinoblastoma (RB) protein / Enhancer of Zeste Homologue 2 (EZH2) / Vasohibin 1 (VASH1) |
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| Research Abstract |
We found an essential role of TG2 in tumor-induced angiogenesis through a comparison between TG2+/+ and TG2-/- mice, which show no abnormal manifestation during development. We provide evidence that TG2 controls crosslinking and phosphorylation of RB proteins and trans-activation of E2F that results in induction of EZH2, which suppresses an anti-angiogenic factor, vasohibin 1 (VASH1), thereby sustaining tumor angiogenesis. Thus, TG2 and under signaling molecules maybe a novel target for anti-angiogenic therapy against cancer, without affecting tissue remodeling.
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