2013 Fiscal Year Final Research Report
Research on differentiation factor and niche for cardiac stem/progenitor cells
| Project/Area Number |
24659381
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
NAGAI TOSHIO 千葉大学, 医学(系)研究科(研究院), 准教授 (00334194)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 分子心臓病態学 |
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| Research Abstract |
We generated alpha-MHCMerCreMer/CAG-CAT-LacZ mice to detect newly formed cardiomyocytes after myocardial infarction. We found that some of the new cardiomyocytes are derived from cardiac stem/progenitor cells after entering the cell cycle. Next we produced a three-dimensional thick scaffold, in which cardiac progenitor cells (CPC) were cultivated in combination with self-assembling peptide and transplanted CPC-scaffold on the surface of myocardial infarction area of alpha-MHCMerCreMer/CAG-CAT-LacZ mice. Transplantation of CPC-scaffold enhanced the formation of new cardiomyocytes. We dissected heart tissue sections by using a laser micro dissection system and then identified several proteins, which expressed exclusively in the transplanted heart.
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Research Products
(12 results)
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[Journal Article] Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells2013
Author(s)
Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I.
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Journal Title
Hypertens Res
Volume: 36
Pages: 859-865
DOI
Peer Reviewed
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[Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012
Author(s)
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.
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Journal Title
Cell
Volume: 149
Pages: 1298-313
DOI
Peer Reviewed
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