2012 Fiscal Year Final Research Report
Macrophage trafficking in adipose tissue inflammation
| Project/Area Number |
24659382
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MANABE Ichiro 東京大学, 医学部附属病院, 講師 (70359628)
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| Project Period (FY) |
2012
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| Keywords | マクロファージ / 炎症 / 脂肪 |
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| Research Abstract |
Obesity induces active inflammatory processes in adipose tissue. In these processes macrophages alter their phenotypes and act as central effector cells. To elucidate the molecular mechanisms underlying the changes in macrophage phenotypes, this study focused on the macrophage trafficking to and from adipose tissue. We developed a novel method to analyze trafficking of adipose tissue macrophages and identified factors that promote the egression of macrophages. We also identified S100 proteins as a regulator of macrophage trafficking.
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[Journal Article] Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation2012
Author(s)
Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R.
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Journal Title
Cell Metabolism
Volume: 15
Pages: 518-533
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